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General
General Scientific Characterization & Product Details
3-Chloromethcathinone (3-CMC, Clophedrone) is a synthetic cathinone that first appeared in Europe in 2014 and has since been seized in 25 countries.The compound is not naturally occurring and is only synthesized chemically.Structurally it is very close to the designer drugs 3-MMC and 4-CMC.3 CMC
rnLegal status and distributionrnIn most European countries - including Germany, Poland, the Netherlands and Sweden - 3-CMC is now subject to narcotics or new psychoactive substances regulations.The yearly increasing seizures (main source: India) show a growing supply on the black market.
rnConsumption and subjective effectsrnConsumers report stimulating, euphoric and sociality-enhancing effects, which are said to be shorter and weaker than with 3-MMC.Common forms of administration are oral ingestion or nasal insufflation.The acute duration of action is stated to be 1-4 hours, after-effects (e.g. insomnia) can last 3-12 hours.
rnAdverse effects and toxicologyrnSystematic safety data are missing;However, clinical observations and analog cathinones suggest tachycardia, hypertension, hyperthermia, anxiety, dry mouth and psychotic episodes.According to EMCDDA, ten deaths (PL: 7, SE: 3) related to 3-CMC were reported between November 2019 and June 2021;in most cases, other substances were involved.
rnChemistryrnIUPAC name: 1-(3-chlorophenyl)-2-(methylamino)propan-1-one.rnThe molecule has a chiral center;commercially available products are almost always racemic.Other positional isomers are 2-CMC and 4-CMC.
rnrnSynthesisrnThe starting material is 3-chloropropiophenone, which is α-brominated and then nucleophilically substituted with methylaminewill.The resulting racemate is usually isolated as a hydrochloride salt.
rnPharmacologyrnIn vitro studies on rat brain synaptosomes (EC₅₀/IC₅₀ in nM):
rn- rn
- rnDopamine transporter (DAT): 26 /342rn
- rnNorepinephrine transporter (NET): 19 / 290rn
- rnSerotonin transporter (SERT): 211 / 1 194rn
3-CMC acts both asMonoamine reuptake inhibitors as well as substrate releasers, with the ratios being shifted in favor of dopamine and norepinephrine (lower SERT affinity compared to mephedrone).In animal studies (rat, monkey) it produces cocaine-like stimulus properties and hyperlocomotion;the reinforcing effect appears to be weaker than with methcathinone, probably due to the higher serotonergic content, which attenuates the dopaminergic effect.
rnMetabolismrnHuman data are almost completely lacking.Like other cathinones, 3-CMC is most likely to undergo hepatic oxidation, reduction and conjugation.Postulated phase I metabolites are dihydro-3-CMC, N-desmethyl-3-CMC and N-desmethyl-dihydro-3-CMC.3 CMC
Customer Reviews
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Frequently Asked Questions
What is the purity level of Buy 3 CMC?
Our Buy 3 CMC is supplied with a guaranteed purity level of at least 99.8%. Every batch undergoes rigorous validation to verify chemical integrity before dispatch. It is ready to use.
Do you sell to individuals?
Yes, we sell to both individuals and businesses. All our products are ready to use.
How are orders packaged and shipped?
Orders are shipped globally using discreet, vacuum-sealed packaging with full end-to-end tracking. Shipments are packed in neutral, heavy-duty parcels to ensure complete privacy and security.
How should Buy 3 CMC be stored?
Store in a cool, dry place at room temperature (15–25 °C), shielded from direct sunlight and excess humidity. Sealed in its original vacuum packaging, chemical stability is preserved for at least 24 months.
External Scientific Registries & Databases
For further chemical specifications, molecular properties, hazard classifications, and reference spectra, consult the following international chemical registries:
PubChem Database National Institutes of Health (NIH) molecular repository. European Chemicals Agency (ECHA) Official EU chemical classification & safety registry. ChemSpider Database Royal Society of Chemistry molecular structure data. NIST Chemistry WebBook Standard reference spectra and gas chromatography data.
