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General Oral dosage (HCl salt, anecdotal) rnrnrnPharmacokineticsrnSystemic data are missing, but users report slow onset (40-120 min), plateau up to 7 h, comedown 2 h and after-effects up to 24 h. rnrn
General Scientific Characterization & Product Details
6-APB (6-(2-aminopropyl)benzofuran) is an empathogenic psychedelic from the benzofuran and phenethylamine family, which is often referred to as “benzofury” in the scene.Structurally, it corresponds to an open-chain variant of MDA in which the 3,4-methylenedioxy ring system has been exchanged for a benzofuran ring;it is also the unsaturated benzofuran version of 6-APDB.The material usually comes into circulation as a brownish, grainy powder.
rnAlthough 6-APB never became a mass-produced product, it had brief guest appearances in the UK rave and club scenes between 2010 and 2013, before import and distribution there fell under the Novel Psychoactive Substances ban.In many other countries, the substance is not explicitly listed to this day, which is why it continues to circulate as a “premium compound” or “legal high”.
rnrnCommon dosage forms and dosagernFreebase, hydrochloride (HCl) and succinate salt are commercially available.Potency scale (calculated):
rn- rn
- rn100 mg 6-APB HCl ≈ 83 mg freebasern
- rn100 mg 6-APB succinate ≈ 60 mg freebasern
- rn
- rnThreshold: 15 mgrn
- rnLight: 15-60 mgrn
- rnCommon: 60-90mgrn
- rnStrong: 90-120 mgrn
- rnHeavy: >120 mgrn
Duration of action (oral)
rn- rn
- rnStart: 30-60 min (up to 2 hours on a full stomach)rn
- rnRise: 1-2 hrn
- rnPlateau: 3-4 hoursrn
- rnDescent: 2-3 hoursrn
- rnTotal: 7-10 hours, after-effects up to 48 hours possiblern
SubjectiveEffectrnEmpathogenic, slightly psychedelic and stimulating effects, comparable to a mixture of MDMA and MDA, but longer lasting and less “pushy”.
rnrnSide and risk profilernAnecdotal reports describe dry mucous membranes, jaw clenching, slight visual distortions and - in combination with synthetic cannabinoids - acute psychoses.
Chronically, the strong 5-HT₂B agonism-based heart valve risk effect (see fenfluramine) is likely to dominate.
rnrnPharmacology (rat synaptosomes)
rn- rn
- rnMonoamine release (EC₅₀):Serotonin 36 nM, norepinephrine 14 nM, dopamine 10 nMrn
- rnReuptake inhibition (IC₅₀): serotonin 930 nM, norepinephrine 190 nM, dopamine 3,300 nMrn
- rn5-HT₂B receptor: Ki 3.7 nM, EC₅₀ 140 nM, Emax 70% (stronger than reference agonist BW-723C86)rn
- rn5-HT₂A: partial agonist, EC₅₀ 5,900nM, Emax 43%rn
- rn5-HT₂C: Ki 270 nM (partially agonistic)rn
- rn5-HT₁A: Ki 1 500 nMrn
- rn
The high 5-HT₂B selectivity (100-fold vs. 5-HT₂A/C) makes long-term cardiac consequences (heart valve fibrosis) likely.
rnrnMetabolism (Rat)rnPhase-I: Furan hydroxylation → ring opening→ Reduction to the unsaturated aldehyde intermediate, then oxidation to the carboxylic acid or reduction to the alcohol with subsequent hydroxylation.Phase-II: Glucuronidation.Main metabolites: 3-carboxymethyl-4-hydroxyamphetamine and 4-carboxymethyl-3-hydroxyamphetamine.
rnrnChemistry / AnalyticsrnColor reagent tests (Marquis, Mecke, Liebermann, Froehde) give uniform violet-to-black results.6-APB succinate is practically insoluble in chloroform and only slightly soluble in cold water;a DEA batch contained succinate and 6-APB in a ratio of 2:1.
rnrnSynthesis (Overview)rnAccording to Briner et al.3-bromophenol is reacted with bromoacetaldehyde diethyl acetal and NaH to form diethyl acetal, then cyclized with polyphosphoric acid (mixture of 4- and 6-bromobenzofuran), separated by column chromatography, oxidized to the propanequinone intermediate and reductively aminated.The resulting 6- or 4-APB freebases are isolated for commercial use as hydrochloride salts.
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Frequently Asked Questions
What is the purity level of Buy 6-APb?
Our Buy 6-APb is supplied with a guaranteed purity level of at least 99.8%. Every batch undergoes rigorous validation to verify chemical integrity before dispatch. It is ready to use.
Do you sell to individuals?
Yes, we sell to both individuals and businesses. All our products are ready to use.
How are orders packaged and shipped?
Orders are shipped globally using discreet, vacuum-sealed packaging with full end-to-end tracking. Shipments are packed in neutral, heavy-duty parcels to ensure complete privacy and security.
How should Buy 6-APb be stored?
Store in a cool, dry place at room temperature (15–25 °C), shielded from direct sunlight and excess humidity. Sealed in its original vacuum packaging, chemical stability is preserved for at least 24 months.
External Scientific Registries & Databases
For further chemical specifications, molecular properties, hazard classifications, and reference spectra, consult the following international chemical registries:
PubChem Database National Institutes of Health (NIH) molecular repository. European Chemicals Agency (ECHA) Official EU chemical classification & safety registry. ChemSpider Database Royal Society of Chemistry molecular structure data. NIST Chemistry WebBook Standard reference spectra and gas chromatography data.
